$29.99
  • 100% Kimchi Probiotics

  • 30 Billion CFUs

  • Vegan Probiotics with Prebiotics

  • Patented Strain(Atopy and Allergy)

Quantity

Shipping calculated at checkout.

  • Description
  • More Information
  • Nutritional Fact

Kflora is derived from 

Korea’s unique superfood: Kimchi.

Kimchi has been used to support gut and immune health

for thousands of years. And now, we’re bringing it to you.

VIABILITY

We use only those probiotic strains that have survived the intense fermentation process needed to make Kimchi - and by extension, the harshest conditions of the gastrointestinal tract. In fact, 90% of these probiotics reach the intestine in a living state - compared to only 20-30% of animal lactic acid bacteria found in other probiotic foods.

PATENTED STRAIN

Lactobacillus Sakei proBio65 is patented* and clinically shown to “Reduce atopic dermatitis(eczema) and allergy-related disorders” by improving immune function.

*US 8,034,606 B2 (Patent No.)

DAILY DIGESTIVE & IMMUNE SUPPORT

Lactobacillus Brevis proBio-96 and Weissella Koreensis proBio-97 replenish friendly bacteria to restore gut health to its optimal state. Enjoy improved digestive and immune function, and find relief from uncomfortable bloating, gas, and constipation.

CLINICALLY PROVEN RESULTS

Lactobacillus Plantarum proBio-92 has been clinically studied and found to have anti-obesity, antioxidant, and antiviral effects.

SHELF STABLE PROBIOTICS

Kflora can be stored stably at room temperature by using a patented container to prevent moisture absorption. This 30 billion probiotics supplement comes in 30 daily capsules; no refrigeration required

THE CELLS

Lactobacillus Sakei Probio 65

The skin is colonized by a diverse microbiota. Some skin diseases have been associated with an altered microbial state, including atopic dermatitis and acne. This strain is a unique probiotic for children and adults that is shown to manage atopic dermatitis through creating a healthy, balanced gut-skin axis.


L. sakei Probio 65 is a versatile patented probiotic strain that delivers positive skin microbiota balancing effects in both live and dead forms, in supplement and topical formulas.

Skin Health

References

Health Benefits of Kimchi(Korean Fermented Vegetables) as a Probiotic Food

Journal of Medical Food Vol. 17, No. 1

Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi

Journal of Applied Microbiology, 2013, Vol. 115;517-526

Effect of Lactobacillus sakei supplementation in children with atopic eczema–dermatitis syndrome

Annals of Allergy, Asthma & Immunology, 2010, Vol. 104;343-348Health Benefits of Kimchi(Korean Fermented Vegetables) as a Probiotic Food

A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis

Journal of Microbiology and Biotechnology, 2015, Vol. 25(11), 1966-1969 

Lactobacillus Plantarum Probio 92 & 

Lactobacillus Brevis Probio 96

These clinical strains and nutrients enhance the immune response in the body, and their site of activity is in the intestines. The intestinal compartment is the most extensive and complex part of the immune system, and up to 80% of the immune cells of the body are located around the intestinal mucosa at any point of time. As a result, the intestinal mucosa is a key factor in the modulation of the overall immune system.


Probiotic microorganisms have a long history of safe use and have been documented for various health benefits. Many strains of lactic acid bacteria (LAB) from the genus of Lactobacillus have been identified to possess probiotic properties. They have been much emphasized for their roles to regulate gut well-being. Recent published studies have illustrated the potential for Lactobacillus plantarum for supporting cognitive health, including protection against negative effects associated with stress and anxiety.

Gastrointestinal Health

Immune Health

Mood & Stress

Kflora Probiotics’ Intensive G.I. is a multi-strain formula that helps to protect against everyday gut related anxiety and discomfort.

A synergistic blend of strains with multiple mechanisms documented in vitro associated with a healthy gut/GI tract.

The clinically tested blend strains of Lactobacillus plantarum and Lactobacillus Brevis, its unique mechanism of action optimized for Gut Health.

In addition, the strains were shown to be strong producers of short chain fatty acids acetate, propionate and butyrate.

References

Antioxidant and immune-enhancing effects of probiotic Lactobacillus plantarum isolated from Kimchi

Food Science and Biotechnology, 2019, Vol. 28(2);491-499

Antioxidant and Anti-Inflammatory Effect of Probiotic Lactobacillus plantarum Derived from Korean Homemade Diced-Radish Kimchi

Journal of Microbiology and Biotechnology, 2020, Vol. 30(4);591-598

Immune-stimulating Effect of Lactobacillus plantarum Isolated from the Traditional Korean Fermented Food, Kimchi

Journal of Microbiology and Biotechnology, 2020, 30(6);926-929

Molecular Characterization of Lactobacillus plantarum YML016(proBio92) with Anti-Diabetic, Anti-Melanogenic and Anti-Viral Efficacy

The National Academy of Science, India 2018, Sept.

Weisella Koreensis

These clinical strain is the predominant lactic acid bacteria (LAB) isolated from kimchi, a traditional Korean fermented-vegetable food


Studies have shown that the LAB isolated during kimchi fermentation exhibit antimicrobial activities by producing compounds such as organic acids, fatty acids and hydrogen peroxide.


W. koreensis, found in kimchi, is associated with L-Ornithine production from arginine. L-Ornithine is a medicinal, non-protein amino acid which has the potential to combat obesity by promoting hormone release and accelerating basal metabolism rate.

Weight Control

References

Weissella koreensis sp. nov., isolated from kimchi

Int. J.Syst. Evol. Microbiol, 2002, 52, 1257– 1261

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

J Appl Microbiol, 2012, 113(3), 652-8.

Lactobacillus Sakei Probio 65

The skin is colonized by a diverse microbiota. Some skin diseases have been associated with an altered microbial state, including atopic dermatitis and acne. This strain is a unique probiotic for children and adults that is shown to manage atopic dermatitis through creating a healthy, balanced gut-skin axis.


L. sakei Probio 65 is a versatile patented probiotic strain that delivers positive skin microbiota balancing effects in both live and dead forms, in supplement and topical formulas.


For the approximate 16.5 million adults1 and 9.6 million infants and children (or 13% of all children)2 in the US with atopic dermatitis, a chronic skin condition also known as eczema, natural relief would be highly welcome, and a safe and easy way to reduce the number of and severity of outbreaks would be even more heartily embraced.


Atopic dermatitis (AD) is a skin disorder characterized by scaling, itchy lesions and excessive dryness, and which is rooted by excessive inflammation. Although pathogenesis of AD is multifactorial it has been reported that up to 90% of AD cases are associated with Staphylococcus aureus ​infection. It has also been shown that the colonization of S. aureus ​in lesional and non-lesional skin is proportional with the severity of AD.


Individuals with AD tend to have a disturbed microbiota composition and a reduced diversity in their gut and skin microbiota. An imbalance of the skin microbiota leaves the skin vulnerable to opportunistic pathogenic bacteria such as Staphylococcus aureus​.


A gap that may be filled by natural products containing research-backed ingredients such as probiotics is that there is a scarcity of long-term effective treatments for AD, and those that exist tend to bring undesirable side effects, such as weight gain, mood disorders and potential liver damage. In children, corticosteroid use may create impaired growth, immunity and adrenal suppression.


L. sakei Probio 65 is a probiotic strain that, in topical products, may improve AD bouts with a once daily application. Lactobacillus sakei​ Probio 65 is a lactic acid bacteria strain obtained from kimchi, a traditional fermented food from Korea. L. sakei Probio 65 is an immune-modulating strain with clinically tested efficacy on AD.


Pre-clinical and clinical research shows that L. sakei Probio 65 is completely safe and free of side effects when used long-term, and it work by creating sturdy balance of the immune system, which reduces severity and frequency of AD symptoms.


Several studies have suggested the possibility of using non-viable lactobacilli for immunomodulation [27,28]. Using animal models, both live and dead cells of L. sakei ​Probio 65 have improved skin condition of AD-induced mice and they exerted a significant reduction of serum immunoglobulin (Ig) E and cutaneous T-cell-attracting chemokines (CTACK). These results suggest that both live and dead cells of L. sakei ​Probio 65 may prevent the development of skin diseases related to skin inflammation such as AD.

Pre-clinical/Animal

Rodent studies have shown efficacy of ingestible viable and heat-inactivated Lactobacillus sakei​ Probio 65 in mice with AD.


In one study, L. sakei Probio 65 was shown to improve the condition of skin and reduce scratching frequency. Testing showed significant reduction in serum levels of IgE and cutaneous T-cell-attracting chemokine (CTACK).


The heat-inactivated probiotic cells also reduced interleukin (IL)-4 and IL-6 serum concentrations; and both live and dead L. sakei​ Probio 65 inhibited the expression of Thymus and activation-regulated chemokine and CTACK in the mice’s AD skin lesions. The increased levels of Foxp3 expression in the lesional areas were also suppressed by L. sakei​ Probio 65. In addition, L. sakei​ Probio 65 inhibited b-hexosaminidase release and the secretion of IL-4, TNF-alpha and IL-6 from RBL-2H3 cells.


The researchers asserted that ingestion both viable and heat-inactivated L. sakei ​Probio 65 inhibits skin inflammation AD-like skin lesions, and mast cell activation. Lactobacillus sakei​ Probio 65 has an inhibitory effect on atopic dermatitis-like skin lesions and may represent an effective new anti-inflammatory agent.


Another rodent study investigated the improvement of allergic dermatitis in chemical allergen-induced mice by Lactobacillus sakei ​Probio 65. Subjects that received L. sakei ​probio 65 showed a more rapid recovery compared to control mice, as assessed by visual evaluation of the severity of allergic dermatitis and levels of IgE and IL-4.4

Human Clinicals

In 2011, researchers discovered the concept of ghost probiotics, which describes the immuno-modulatory properties of non-viable probiotics. Although seemingly contradictory to the long-held belief that only live probiotics (of all strains) are biologically functional, the use of non-viable (“dead”) probiotic strains has grown significantly due to their better stability and safety over their viable counterpart. (Note: the potential use of non-viable probiotics should be compared only to viable cells of the same strain.) Previously, the efficacy and comparison between both of viable and non-viable probiotics on alleviation of AD has not been well studied.


The goal of one human study was to evaluate the efficacy of both live and dead cells of L. sakei ​Probio65 when orally consumed by children and adolescents aged 3 to 9 and 10 to 18, respectively, with mild to moderate AD.


In this randomized double-blind, placebo-controlled 12-week study, 58 subjects supplemented with either the L. sakei​ Probio 65 live cells, L. sakei Probio 65 dead cells, or placebo groups.


Assessment of efficacy was based on the change in SCORing Atopic Dermatitis (SCORAD) score, and changes in skin condition (moisture and sebum) as well as numerous inflammatory biomarkers at baseline, and at weeks 6 and 12. The results were encouraging: the SCORAD total score decreased in the live cells and dead cells group compared to baseline, whereas there were no significant changes in the placebo group when compared to baseline. The skin sebum content increased in both the live cell and the dead cell group, suggesting potential improvements in skin barrier functions. The researchers concluded that supplementing with L. sakei​ Probio 65 in both viable and non-viable forms provided a positive improvement in alleviation of AD symptoms.5


One study delivered Lactobacillus sakei​ Probio 65 in a topical formulation to assess performance on AD symptoms. In the double-blind, randomized, split-body clinical trial, 28 subjects with AD applied the Lactobacillus-​containing emollient on one side of their body and the control emollient on the other side twice daily for 4 weeks. Trans-epidermal water loss (TEWL) and skin capacitance were evaluated.

The treated sides had significantly lower TEWL and VAS values and significantly higher skin capacitance values over time than the control sides, leading the researchers to demonstratively conclude that application of Lactobacillus-​containing emollients (e.g., L. sakei Probio 65) may improve the skin permeability of individuals with AD.6


Researchers in another study evaluated the clinical efficacy of Lactobacillus sakei ​Probio 65, which previously was shown to exert the most potent inhibitory activity against Staphylococcus aureus ​growth among Lactobacillus ​species. In the study of 75 children aged 2 to 10 with severe atopic eczema-dermatitis syndrome, the probiotic strain was compared to placebo to discern clinical outcome and measure levels of serum chemokines (markers for AEDS).


At week 12, researchers marked a 31% (13.1-point) improvement in mean AD activity with probiotic use compared with a 13% (5.2-point) improvement with placebo use. Significant differences in favor of probiotic treatment were also observed in proportions of participants achieving improvement of at least 30% and 50%. Compared with placebo, probiotic administration was associated with lower pretreatment-adjusted serum levels of CCL17 and CCL27 which were significantly correlated with SCORAD total score.


Supplementation of L. sakei ​in children with AEDS was associated with a substantial clinical improvement and a significant decrease in chemokine levels, reflecting the severity of AEDS.7

References:​

1.  Fuxench ZCC, “Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population” J Invest Dermatol​ 2019, 139(3) 583-590
2.  National Eczema Association; www.nationaleczema.org​
3.  Kim J-Y, et al​. “Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi” J Appl Microbiol​ 2013, 115(2), 517-526
4.  Park CW, et al​. “New Functional Probiotic Lactobacillus sakei ​Probio 65 Alleviates Atopic Symptoms in the Mouse” J Med Food ​2008, 11(3), 405–412
5.  Rather IA, et al​. “Oral administration of live and dead cells of Lactobacillus sakei Probio65 alleviated atopic dermatitis in children and adolescents: A randomized, double-blind and placebo-controlled study” Probiotics and Antimicrobial Proteins​ 2021,13(2), 315-326
6.  Park BP, et al​. “Effect of Emollients Containing Vegetable-Derived Lactobacillus in the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial” Ann Dermatol​ 2014, 26(2), 150-155
7.  Woo S-I, et al​. “Effect of Lactobacillus sakei supplementation in children with atopic eczema-dermatitis syndrome.” Ann Allergy Asthma Immunol. ​2010,104(4), 343–348.

Product Usage

1 capsule/day with or without meal.

Disclaimer

biola is not responsible for the structure function claims used in advertising of consumer-packaged goods that contain L. sakei Probio 65. This communication is for informational purposes only, and its content is not to be construed as advice regarding advertising claims. Before advertising consumer packaged goods that contain L. sakei Probio 65, please consult a federal regulatory attorney experienced in the FTC and FDA regulations governing the advertising of dietary supplements.​

Customer Reviews

Based on 40 reviews
80%
(32)
15%
(6)
5%
(2)
0%
(0)
0%
(0)
E
Eileen Donovan
Best probiotic ever

Keeps my psoriasis away. I take one in the morning and one st night. Psoriasis 98% gone. Thank you for a great product

K
Kelly Vereen

[1 Pack] Kflora 100% KIMCHI PROBIOTICS (500mg 30 Capsules)

W
WibboWibbo
Kinch--derived pre- and probiotics in capsule form, but expensive.

The white capsules are medium sized and relatively easy to swallow with plenty of water.There was no discernable odor or taste and no aftertaste.Vegan and no refrigeration is required.The outer box, not not the inner capsule bottle, was sealed with a tamper-evident seal. This is good to ensure that the box was not tampered with, but there's no way to know if the bottle was opened or tampered with after manufacture.The ingredients are listed on the product page for anyone who may have ingredient sensitivities, and there's a good description of what the capsules contain and the uses and benefits they provide.What's missing, though, from the product page and the included literature are the details on the "clinical studies," Where where these studied, what were they studied for, and where are the results?Priced at $40 for about a month's supply, these are an expensive alternative to fresh kimchi. They are a convenient alternative for those who may not have access to or like the taste of fresh kimchi.

s
smiledesignersmiledesigner
Great product, best delivery

Great product, best delivery

T
The Artist Formerly Known as ʢ
Unique kimchi based probiotics and L. Sakei for sinus health but pricy and full of fillers

I was interested to try these probiotics because they had a special one from Kimchi that I hadn't heard of or taken. In addition this probiotic has L. Sakei, which is hard to find and it's especially good for oral health and sinus issues. The CFU count is decent and it doesn't need to be refrigerated and also has FOS to help feed the probiotics.That being said this is only a 30 day supply and the amount of fillers per pill is horrific and on par or worse than drug store probiotics: Microcrystalline cellulose, Dextrin, Silicon dioxide, Magnesium stearate, Capsule(Hydroxypropyl methylcellulose, Purified Water, Carrageenan, Sucrose esters of fatty acids, Magnesium chloride, Potassium chloride, D-Sorbitol solution)Yuck! It's been a while since I saw a pill with so many fillers. The fact that it had so many made me skip this probiotic more often than not. I generally don't respond obviously to any probiotic so I can't say if this helped good or bad.I'm glad that this company is bringing unique probiotics to the market but at this price for a 30 day supply, I don't understand the need for that many junk fillers.

  • Description
  • More Information
  • Nutritional Fact

Kflora is derived from 

Korea’s unique superfood: Kimchi.

Kimchi has been used to support gut and immune health

for thousands of years. And now, we’re bringing it to you.

VIABILITY

We use only those probiotic strains that have survived the intense fermentation process needed to make Kimchi - and by extension, the harshest conditions of the gastrointestinal tract. In fact, 90% of these probiotics reach the intestine in a living state - compared to only 20-30% of animal lactic acid bacteria found in other probiotic foods.

PATENTED STRAIN

Lactobacillus Sakei proBio65 is patented* and clinically shown to “Reduce atopic dermatitis(eczema) and allergy-related disorders” by improving immune function.

*US 8,034,606 B2 (Patent No.)

DAILY DIGESTIVE & IMMUNE SUPPORT

Lactobacillus Brevis proBio-96 and Weissella Koreensis proBio-97 replenish friendly bacteria to restore gut health to its optimal state. Enjoy improved digestive and immune function, and find relief from uncomfortable bloating, gas, and constipation.

CLINICALLY PROVEN RESULTS

Lactobacillus Plantarum proBio-92 has been clinically studied and found to have anti-obesity, antioxidant, and antiviral effects.

SHELF STABLE PROBIOTICS

Kflora can be stored stably at room temperature by using a patented container to prevent moisture absorption. This 30 billion probiotics supplement comes in 30 daily capsules; no refrigeration required

THE CELLS

Lactobacillus Sakei Probio 65

The skin is colonized by a diverse microbiota. Some skin diseases have been associated with an altered microbial state, including atopic dermatitis and acne. This strain is a unique probiotic for children and adults that is shown to manage atopic dermatitis through creating a healthy, balanced gut-skin axis.


L. sakei Probio 65 is a versatile patented probiotic strain that delivers positive skin microbiota balancing effects in both live and dead forms, in supplement and topical formulas.

Skin Health

References

Health Benefits of Kimchi(Korean Fermented Vegetables) as a Probiotic Food

Journal of Medical Food Vol. 17, No. 1

Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi

Journal of Applied Microbiology, 2013, Vol. 115;517-526

Effect of Lactobacillus sakei supplementation in children with atopic eczema–dermatitis syndrome

Annals of Allergy, Asthma & Immunology, 2010, Vol. 104;343-348Health Benefits of Kimchi(Korean Fermented Vegetables) as a Probiotic Food

A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis

Journal of Microbiology and Biotechnology, 2015, Vol. 25(11), 1966-1969 

Lactobacillus Plantarum Probio 92 & 

Lactobacillus Brevis Probio 96

These clinical strains and nutrients enhance the immune response in the body, and their site of activity is in the intestines. The intestinal compartment is the most extensive and complex part of the immune system, and up to 80% of the immune cells of the body are located around the intestinal mucosa at any point of time. As a result, the intestinal mucosa is a key factor in the modulation of the overall immune system.


Probiotic microorganisms have a long history of safe use and have been documented for various health benefits. Many strains of lactic acid bacteria (LAB) from the genus of Lactobacillus have been identified to possess probiotic properties. They have been much emphasized for their roles to regulate gut well-being. Recent published studies have illustrated the potential for Lactobacillus plantarum for supporting cognitive health, including protection against negative effects associated with stress and anxiety.

Kflora Probiotics’ Intensive G.I. is a multi-strain formula that helps to protect against everyday gut related anxiety and discomfort.


The clinically tested blend strains of Lactobacillus plantarum and Lactobacillus Brevis, its unique mechanism of action optimized for Gut Health.

A synergistic blend of strains with multiple mechanisms documented in vitro associated with a healthy gut/GI tract.


In addition, the strains were shown to be strong producers of short chain fatty acids acetate, propionate and butyrate.

References

Antioxidant and immune-enhancing effects of probiotic Lactobacillus plantarum isolated from Kimchi

Food Science and Biotechnology, 2019, Vol. 28(2);491-499

Antioxidant and Anti-Inflammatory Effect of Probiotic Lactobacillus plantarum Derived from Korean Homemade Diced-Radish Kimchi

Journal of Microbiology and Biotechnology, 2020, Vol. 30(4);591-598

Immune-stimulating Effect of Lactobacillus plantarum Isolated from the Traditional Korean Fermented Food, Kimchi

Journal of Microbiology and Biotechnology, 2020, 30(6);926-929

Molecular Characterization of Lactobacillus plantarum YML016(proBio92) with Anti-Diabetic, Anti-Melanogenic and Anti-Viral Efficacy

The National Academy of Science, India 2018, Sept.

Weisella Koreensis

These clinical strain is the predominant lactic acid bacteria (LAB) isolated from kimchi, a traditional Korean fermented-vegetable food


Studies have shown that the LAB isolated during kimchi fermentation exhibit antimicrobial activities by producing compounds such as organic acids, fatty acids and hydrogen peroxide.


W. koreensis, found in kimchi, is associated with L-Ornithine production from arginine. L-Ornithine is a medicinal, non-protein amino acid which has the potential to combat obesity by promoting hormone release and accelerating basal metabolism rate.

Weight Control

References

Weissella koreensis sp. nov., isolated from kimchi

Int. J.Syst. Evol. Microbiol, 2002, 52, 1257– 1261

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

J Appl Microbiol, 2012, 113(3), 652-8.

Lactobacillus Sakei Probio 65

The skin is colonized by a diverse microbiota. Some skin diseases have been associated with an altered microbial state, including atopic dermatitis and acne. This strain is a unique probiotic for children and adults that is shown to manage atopic dermatitis through creating a healthy, balanced gut-skin axis.


L. sakei Probio 65 is a versatile patented probiotic strain that delivers positive skin microbiota balancing effects in both live and dead forms, in supplement and topical formulas.


For the approximate 16.5 million adults1 and 9.6 million infants and children (or 13% of all children)2 in the US with atopic dermatitis, a chronic skin condition also known as eczema, natural relief would be highly welcome, and a safe and easy way to reduce the number of and severity of outbreaks would be even more heartily embraced.


Atopic dermatitis (AD) is a skin disorder characterized by scaling, itchy lesions and excessive dryness, and which is rooted by excessive inflammation. Although pathogenesis of AD is multifactorial it has been reported that up to 90% of AD cases are associated with Staphylococcus aureus ​infection. It has also been shown that the colonization of S. aureus ​in lesional and non-lesional skin is proportional with the severity of AD.


Individuals with AD tend to have a disturbed microbiota composition and a reduced diversity in their gut and skin microbiota. An imbalance of the skin microbiota leaves the skin vulnerable to opportunistic pathogenic bacteria such as Staphylococcus aureus​.


A gap that may be filled by natural products containing research-backed ingredients such as probiotics is that there is a scarcity of long-term effective treatments for AD, and those that exist tend to bring undesirable side effects, such as weight gain, mood disorders and potential liver damage. In children, corticosteroid use may create impaired growth, immunity and adrenal suppression.


L. sakei Probio 65 is a probiotic strain that, in topical products, may improve AD bouts with a once daily application. Lactobacillus sakei​ Probio 65 is a lactic acid bacteria strain obtained from kimchi, a traditional fermented food from Korea. L. sakei Probio 65 is an immune-modulating strain with clinically tested efficacy on AD.


Pre-clinical and clinical research shows that L. sakei Probio 65 is completely safe and free of side effects when used long-term, and it work by creating sturdy balance of the immune system, which reduces severity and frequency of AD symptoms.


Several studies have suggested the possibility of using non-viable lactobacilli for immunomodulation [27,28]. Using animal models, both live and dead cells of L. sakei ​Probio 65 have improved skin condition of AD-induced mice and they exerted a significant reduction of serum immunoglobulin (Ig) E and cutaneous T-cell-attracting chemokines (CTACK). These results suggest that both live and dead cells of L. sakei ​Probio 65 may prevent the development of skin diseases related to skin inflammation such as AD.

Pre-clinical/Animal

Rodent studies have shown efficacy of ingestible viable and heat-inactivated Lactobacillus sakei​ Probio 65 in mice with AD.


In one study, L. sakei Probio 65 was shown to improve the condition of skin and reduce scratching frequency. Testing showed significant reduction in serum levels of IgE and cutaneous T-cell-attracting chemokine (CTACK).


The heat-inactivated probiotic cells also reduced interleukin (IL)-4 and IL-6 serum concentrations; and both live and dead L. sakei​ Probio 65 inhibited the expression of Thymus and activation-regulated chemokine and CTACK in the mice’s AD skin lesions. The increased levels of Foxp3 expression in the lesional areas were also suppressed by L. sakei​ Probio 65. In addition, L. sakei​ Probio 65 inhibited b-hexosaminidase release and the secretion of IL-4, TNF-alpha and IL-6 from RBL-2H3 cells.


The researchers asserted that ingestion both viable and heat-inactivated L. sakei ​Probio 65 inhibits skin inflammation AD-like skin lesions, and mast cell activation. Lactobacillus sakei​ Probio 65 has an inhibitory effect on atopic dermatitis-like skin lesions and may represent an effective new anti-inflammatory agent.


Another rodent study investigated the improvement of allergic dermatitis in chemical allergen-induced mice by Lactobacillus sakei ​Probio 65. Subjects that received L. sakei ​probio 65 showed a more rapid recovery compared to control mice, as assessed by visual evaluation of the severity of allergic dermatitis and levels of IgE and IL-4.4

Human Clinicals

In 2011, researchers discovered the concept of ghost probiotics, which describes the immuno-modulatory properties of non-viable probiotics. Although seemingly contradictory to the long-held belief that only live probiotics (of all strains) are biologically functional, the use of non-viable (“dead”) probiotic strains has grown significantly due to their better stability and safety over their viable counterpart. (Note: the potential use of non-viable probiotics should be compared only to viable cells of the same strain.) Previously, the efficacy and comparison between both of viable and non-viable probiotics on alleviation of AD has not been well studied.


The goal of one human study was to evaluate the efficacy of both live and dead cells of L. sakei ​Probio65 when orally consumed by children and adolescents aged 3 to 9 and 10 to 18, respectively, with mild to moderate AD.


In this randomized double-blind, placebo-controlled 12-week study, 58 subjects supplemented with either the L. sakei​ Probio 65 live cells, L. sakei Probio 65 dead cells, or placebo groups.


Assessment of efficacy was based on the change in SCORing Atopic Dermatitis (SCORAD) score, and changes in skin condition (moisture and sebum) as well as numerous inflammatory biomarkers at baseline, and at weeks 6 and 12. The results were encouraging: the SCORAD total score decreased in the live cells and dead cells group compared to baseline, whereas there were no significant changes in the placebo group when compared to baseline. The skin sebum content increased in both the live cell and the dead cell group, suggesting potential improvements in skin barrier functions. The researchers concluded that supplementing with L. sakei​ Probio 65 in both viable and non-viable forms provided a positive improvement in alleviation of AD symptoms.5


One study delivered Lactobacillus sakei​ Probio 65 in a topical formulation to assess performance on AD symptoms. In the double-blind, randomized, split-body clinical trial, 28 subjects with AD applied the Lactobacillus-​containing emollient on one side of their body and the control emollient on the other side twice daily for 4 weeks. Trans-epidermal water loss (TEWL) and skin capacitance were evaluated.

The treated sides had significantly lower TEWL and VAS values and significantly higher skin capacitance values over time than the control sides, leading the researchers to demonstratively conclude that application of Lactobacillus-​containing emollients (e.g., L. sakei Probio 65) may improve the skin permeability of individuals with AD.6


Researchers in another study evaluated the clinical efficacy of Lactobacillus sakei ​Probio 65, which previously was shown to exert the most potent inhibitory activity against Staphylococcus aureus ​growth among Lactobacillus ​species. In the study of 75 children aged 2 to 10 with severe atopic eczema-dermatitis syndrome, the probiotic strain was compared to placebo to discern clinical outcome and measure levels of serum chemokines (markers for AEDS).


At week 12, researchers marked a 31% (13.1-point) improvement in mean AD activity with probiotic use compared with a 13% (5.2-point) improvement with placebo use. Significant differences in favor of probiotic treatment were also observed in proportions of participants achieving improvement of at least 30% and 50%. Compared with placebo, probiotic administration was associated with lower pretreatment-adjusted serum levels of CCL17 and CCL27 which were significantly correlated with SCORAD total score.


Supplementation of L. sakei ​in children with AEDS was associated with a substantial clinical improvement and a significant decrease in chemokine levels, reflecting the severity of AEDS.7

References:​

1.  Fuxench ZCC, “Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population” J Invest Dermatol​ 2019, 139(3) 583-590
2.  National Eczema Association; www.nationaleczema.org​
3.  Kim J-Y, et al​. “Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi” J Appl Microbiol​ 2013, 115(2), 517-526
4.  Park CW, et al​. “New Functional Probiotic Lactobacillus sakei ​Probio 65 Alleviates Atopic Symptoms in the Mouse” J Med Food ​2008, 11(3), 405–412
5.  Rather IA, et al​. “Oral administration of live and dead cells of Lactobacillus sakei Probio65 alleviated atopic dermatitis in children and adolescents: A randomized, double-blind and placebo-controlled study” Probiotics and Antimicrobial Proteins​ 2021,13(2), 315-326
6.  Park BP, et al​. “Effect of Emollients Containing Vegetable-Derived Lactobacillus in the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial” Ann Dermatol​ 2014, 26(2), 150-155
7.  Woo S-I, et al​. “Effect of Lactobacillus sakei supplementation in children with atopic eczema-dermatitis syndrome.” Ann Allergy Asthma Immunol. ​2010,104(4), 343–348.

Product Usage

1 capsule/day with or without meal.

Disclaimer

biola is not responsible for the structure function claims used in advertising of consumer-packaged goods that contain L. sakei Probio 65. This communication is for informational purposes only, and its content is not to be construed as advice regarding advertising claims. Before advertising consumer packaged goods that contain L. sakei Probio 65, please consult a federal regulatory attorney experienced in the FTC and FDA regulations governing the advertising of dietary supplements.​

Customer Reviews

Based on 40 reviews
80%
(32)
15%
(6)
5%
(2)
0%
(0)
0%
(0)
E
Eileen Donovan
Best probiotic ever

Keeps my psoriasis away. I take one in the morning and one st night. Psoriasis 98% gone. Thank you for a great product

K
Kelly Vereen

[1 Pack] Kflora 100% KIMCHI PROBIOTICS (500mg 30 Capsules)

W
WibboWibbo
Kinch--derived pre- and probiotics in capsule form, but expensive.

The white capsules are medium sized and relatively easy to swallow with plenty of water.There was no discernable odor or taste and no aftertaste.Vegan and no refrigeration is required.The outer box, not not the inner capsule bottle, was sealed with a tamper-evident seal. This is good to ensure that the box was not tampered with, but there's no way to know if the bottle was opened or tampered with after manufacture.The ingredients are listed on the product page for anyone who may have ingredient sensitivities, and there's a good description of what the capsules contain and the uses and benefits they provide.What's missing, though, from the product page and the included literature are the details on the "clinical studies," Where where these studied, what were they studied for, and where are the results?Priced at $40 for about a month's supply, these are an expensive alternative to fresh kimchi. They are a convenient alternative for those who may not have access to or like the taste of fresh kimchi.

s
smiledesignersmiledesigner
Great product, best delivery

Great product, best delivery

T
The Artist Formerly Known as ʢ
Unique kimchi based probiotics and L. Sakei for sinus health but pricy and full of fillers

I was interested to try these probiotics because they had a special one from Kimchi that I hadn't heard of or taken. In addition this probiotic has L. Sakei, which is hard to find and it's especially good for oral health and sinus issues. The CFU count is decent and it doesn't need to be refrigerated and also has FOS to help feed the probiotics.That being said this is only a 30 day supply and the amount of fillers per pill is horrific and on par or worse than drug store probiotics: Microcrystalline cellulose, Dextrin, Silicon dioxide, Magnesium stearate, Capsule(Hydroxypropyl methylcellulose, Purified Water, Carrageenan, Sucrose esters of fatty acids, Magnesium chloride, Potassium chloride, D-Sorbitol solution)Yuck! It's been a while since I saw a pill with so many fillers. The fact that it had so many made me skip this probiotic more often than not. I generally don't respond obviously to any probiotic so I can't say if this helped good or bad.I'm glad that this company is bringing unique probiotics to the market but at this price for a 30 day supply, I don't understand the need for that many junk fillers.